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Giovanni Pacini

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  • Curriculum vitae

    • 1980-1985 Visiting Scientist and Visiting Professor at the Department of Physiology and Biophysics of the University of Southern California, Los Angeles.
    • 1991-2001 Chairman of LADSEB-CNR, Padova, Italy.
    • 1993-94 Professor of The use of computers in the study of elderly subjects at the School of Medicine of the University of Modena, Italy.
    • 1995 - 2001 Chairman of IMEKO Technical Committee #13 Measurement in Medicine and Biology.
    • 1995-present Research Director (Dirigente di Ricerca) at LADSEB-CNR (now ISIB), Padova, Italy.
    • Associate editor Diabetologia
    • Editorial board Measurements


  • Research Interests

      Quantitative assessment of pathophysiological processes such as:
    • glucose/insulin interrelationships;
    • insulin resistance;
    • β-cell secretion;
    • pharmacokinetics of pancreatic peptides;
    • renal function in diabetic subjects through experiment design, mathematical modeling, statistical analysis.

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  • Publications 2006-2009

    • Sörhede-Winzell M, Pacini G, Ahrén B. Insulin secretion after dietary supplementation of conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin resistant mice. Am J Physiol - Endocrinol Metab. 290:E347-E354, 2006
    • Parretti E, Lapolla A, Dalfrà MG, Pacini G, Mari A, Cioni R, Marzari C, Scarselli G, Mello G. Peeclampsia in lean normotensive normotolerant pregnant women can be predicted by simple insulin sensitivity indexes. Hypertension 47:449-453, 2006
    • Pacini G. The hyperbolic equilibrium between insulin sensitivity and secretion. Nutr Metab Cardiovasc Dis 16:S22-S27, 2006
    • Farhan S, Winzer C, Tura A, Quehenberger P, Bieglmaier C, Wagner OF, Huber K, Waldhäusl W, Pacini G, Kautzky-Willer A. Fibrinolytic dysfunction in insulin-resistant women with previous gestational diabetes. Eur J Clin Invest. 36:345-352, 2006
    • Stadler M, Anderwald C, Karer T, Tura A, Kästenbauer T, Auinger M, Bieglmayer C, Wagner O, Kronenberg F, Nowotny P, Pacini G, Prager R. Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation. A sign of impaired beta cell function? Diabetes Care 29:1031-1038, 2006
    • Tura A, Kautzky-Willer A, Pacini G. Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT. Diabetes Research and Clinical Practice 72:298-301, 2006
    • Brehm A, Thomaseth K, Bernroider E, Nowotny P, Waldhäusl W, Pacini G, Roden M. The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests. J Clin Endocrinol Metab 91:2272-2278, 2006
    • Ahrén B, Pacini G. A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1?. American Journal of Physiology - Regul Integr Comp Physiol 291:R131-R137, 2006
    • Kautzky-Willer A, Tura A, Winzer C, Wagner OF, Ludvik B, Hanusch-Enserer U, Prager R, Pacini G. Insulin sensitivity during oral glucose tolerance test and its relations to parameters of glucose metabolism and endothelial function in type 2 diabetic subjects under metformin and thiazolidinedione. Diabetes Obesity and Metabolism 8:561-567, 2006
    • Jönsson T, Ahrén B, Pacini G, Sundler F, Wierup N, Steen S, Sjöberg T, Ugander M, Frosteg ård J, Göransson L, Lindeberg S. A paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutrition & Metabolism 3:39, 2006
    • Basili S, Pacini G, Guagnano MT, Manigrasso MR, Santilli F, Pettinella C, Ciabattoni G, Patrono C, Dav ì G. Insulin resistance as a determinant of platelet activation in obese women. J Am College Cardiology 48:2531-2538, 2006
    • Gasic S, Winzer Ch, Bayerle-Eder M, Roden A, Pacini G, Kautzky-Willer A. Impaired cardiac autonomic function in women with prior gestational diabetes mellitus. Eur J Clin Invest 37:42-47, 2007
    • Morbiducci U, Di Benedetto G, Kautzky-Willer A, Pacini G, Tura A.Improved usability of the minimal model of insulin sensitivity based on an automated approach and genetic algorithms for parameter estimation. Clin Sci 112:257-263, 2007
    • Tura A, Maran A, Pacini G. Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria. Diab Res Clin Pract 77:16-40, 2007
    • Thomaseth K, Pavan A, Pacini G, Ahrén B. Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice. Am J Physiol Endocrinol Metab 292:E1808-E1814, 2007
    • Haider DG, Handisurya A, Storka A, Vojtassakova E, Tura A, Luger A, Pacini G, Wolzt M, Kautzky Willer A. Visfatin response to glucose is reduced in women with gestational diabetes mellitus. Diabetes Care 30:1889-1891, 2007
    • Tura A, Sbrignadello S, Barison S, Conti S, Pacini G. Impedance spectroscopy of solutions at physiological glucose concentrations. Biophysical Chemistry 129:235-241, 2007
    • Pleiner J, Mittermayer F, Langenberger H, Winzer C, Schaller G, Pacini G, Kautzky-Willer A, Tura A, Wolzt M. Impaired vascular nitric oxide bioactivity in women with previous gestational diabetes. Wien Klin Wochenschr 119:483-489, 2007
    • Anderwald C, Anderwald-Stadler M, Promintzer M, Prager G, Mandl M, Nowotny P, Bischof MG, Wolzt M, Ludvik B, Kästenbauer T, Pacini G, Luger A, Krebs M. The clamp-like index: a novel and highly sensitive insulin sensitivity index to calculate hyperinsulinemic clamp glucose infusion rates from oral glucose tolerance test in nondiabetic subjects. Diabetes Care 30:2374-2380, 2007
    • Ahrén B, Pacini G, Tura A, Foley JE, Schweizer A. Improved meal-related insulin processing contributes to the enhancement of B-cell function by the DPP-4 inhibitor vildagliptin in patients with type 2 diabetes. Horm Metab Res 39:826-829, 2007
    • Lapolla A, Dalfrà MG, Mello G, Parretti E, Cioni R, Marzari C, Masin M, Ognibene A, Messeri G, Fedele D, Mari A, Pacini G. Early detection of insulin sensitivity and beta-cell function with simple tests indicates future derangements in late pregnancy. J Clin Endocrinol Metab 93:876-880, 2008
    • Anderwald C, Pfeiler G, Nowotny P, Anderwald-Stadler M, Krebs M, Bischof MG, Kozakova M, Luger A, Pacini G, Roden M, Waldhäusl W. Glucose turnover and intima media thickness of internal carotid artery in type-2 diabetes offspring. Eur J Clin Invest 38:227-237, 2008
    • Ahrén B, Sörhede Winzell M, Pacini G. The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice. J Endocrinol 197:181-187, 2008
    • O'Gorman DJ, Yousif O, Dixon G, McQuaid S, Murphy E, Rahman Y, Gasparro D, Pacini G, Newsholme P, Nolan JJ. In vivo and in vitro studies of GAD antibody positive subjects with type 2 diabetes: a distinct sub phenotype. Diabetes Res Clin Pract 80:365 370, 2008
    • Mari A, Tura A, Pacini G, Kautzky-Willer A, Ferrannini E. Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes. Diabetic Medicine 25:671-677, 2008
    • Ludvik B, Hanefeld M, Pacini G. Improved metabolic control by Ipomoea batatas (Caiapo) is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects. Diabetes, Obesity and Metabolism 10:586-592, 2008
    • Tura A, Mari A, Prikoszovich T, Pacini G, Kautzky-Willer A. Value of the intravenous and oral glucose tolerance tests for detecting subtle impairments in insulin sensitivity and beta-cell function in former gestational diabetes. Clinical Endocrinology 69:237-243, 2008
    • Vrbikova J, Hill M, Bendlova B, Grimmichova T, Dvorakova K, Vondra K, Pacini G. Incretin levels in polycystic ovary syndrome. Eur J Endocrinol 159:121-127, 2008
    • Home PD, Pacini G. Hepatic dysfunction and insulin insensitivity in type 2 diabetes mellitus: a critical target for insulin-sensitizing agents. Diabetes Obesity Metabolism 10:699-718, 2008
    • Thomaseth K, Pacini G, Morelli P, Tonolo G, Nosadini R. Importance of glycemic control on the course of glomerular filtration rate in type 2 diabetes with hypertension and microalbuminuria under tight blood pressure control. Nutr Metab Cardiovasc Dis 18:632-638, 2008
    • Handisurya A, Pacini G, Tura A, Gessl A, Kautzky Willer A. Effects of T4 replacement therapy on glucose metabolism in subjects with subclinical (SH) and overt hypothyroidism (OH). Clin Endocrinol 69:963 969, 2008
    • Szendrödi J, Zwettler E, Schmid AI, Chmelik M, Pacini G, Kacerovsky G, Smekal G, Nowotny P, Wagner O, Schnack C, Schernthaner G, Klaushofer K, Roden M. Reduced basal ATP synthetic flux of skeletal muscle in patients with previous acromegaly. PloS ONE 3:e3958, 2008
    • Musso G, Gambino R, Pacini G, De Michieli F, Cassader M. Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in non-alcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. Am J Clin Nutr 89:558-567, 2009
    • Musso G, Gambino R, Pacini G, Pagano G, Durazzo M, Cassader M. Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. Hepatology 49:426-435, 2009
    • Clodi M, Resl M, Stelzeneder D, Pacini G, Tura A, Mörtl D, Struck J, Morgenthaler NG, A.Bergmann A, Riedl M, Anderwald Stadler M, Luger A, Pacher R, H ülsmann M. Interactions of glucose metabolism and chronic heart failure. Exp Clin Endocrinol Diabetes 117:99-106, 2009
    • Roden M, Mariz S, Brazzale AR, Pacini G. Free fatty acid kinetics during long term treatment with pioglitazone added to added to sulfonylurea or metformin in type 2 diabetes. J Internal Medicine 265:476-487, 2009
    • Pacini G, Ahrén M, Ahrén B. Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice. Am J Physiol Regul Integr Comp Physiol 296:R1316 R1324, 2009

    Journal publications in MedLine
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